I recently stopped following (unfollowed) over 400 people for doing at least one of these:

1. Using the Twitter Bird icon as a picture or using an image that’s too sexy or inappropriate — very unprofessional.
2. Not listing a city and state or saying “home” or some other obscure place out in the middle of the ocean as their location.
3. Posting more than three times in a row. Nobody likes a blabber mouth.
4. Using these words or phrases: CASH, make money, increase followers, secret, Coach, white teeth and financial independence. These are red flags that tell me not to trust you or that you’re unprofessional.
5. Having a weak Profile Bio that contains typos.
6. Posting too many quotes. Say something original for God’s sake.
7. You asked a question. I responded. You didn’t answer or acknowledge me. Admit it, you just asked the question to be seen and didn’t care about my answer. Don’t waste my time, I value it.

I am now very selective of who I follow, I select them individually by their interests, professionalism and location. Since I’ve cleaned up my following list, reading relevant business posts is so much easier because I no longer have to search through a stream of clutter.